Parkinson's disease: controlling movement difficulties
The spontaneous electrical activity of dopaminergic neurons enables us to make smooth movements. While it has been shown that the entry of calcium into these neurons renders them vulnerable, several research groups have focused upon the role of calcium channels in the spontaneous electrical activity of dopaminergic neurons. Is it possible to block the entry of calcium in order to preserve these nerve cells, without altering their spontaneous activity? After years of debate, ULg researchers have now contributed to this issue. Their study, which combines mathematical modelling and experiments, is published in PLoS Computational Biology (1).
(1) Guillaume Drion, Laurent Massotte, Rodolphe Sepulchre and Vincent Seutin. How Modeling Can Reconcile Apparently Discrepant Experimental Results: The Case of Pacemaking in Dopaminergic Neurons. PLoS Comput Biol, 2011, 7(5): e1002050. doi:10.1371/journal.pcbi.1002050