Michel Frédérich is senior research fellow at FNRS (Fonds National de la Recherche Scientifique), and senior lecturer at the pharmacy department of the University of Liège. He began his work there in 1996 by working on the antiplasmodial and anticarcinogenic properties of the Strychnos, a family of plants whose alkaloids were believed to fight malaria, and which had earlier been studied in the seventies for its curative properties by Professor Luke Angenot, the current director of the department. He based his doctoral thesis on the subject, entitled «Isolation and Determination of indole alkaloid structure. Study of their effect on Plasmodium falciparum» and his laureate thesis, entitled «Contribution to the study of natural substances with antiplasmodial and cytotoxic potential. Isolation, determination of structure by high magnetic nuclear resonance imaging, and pharmacological evaluation».

Selection of publications

JANSEN O., FREDERICH M., TITS M., ANGENOT L., COUSINEAU S., BESSOT L., CRUNET C. and NICOLAS J-P., Ethnopharmacologie et paludisme au Burkina Faso: sélection de 13espèces à potentialités antiplasmodiales méconnues, in Ethnopharmacologia 41, 2008, 74-81.

JONVILLE M-C., KODJA H., HUMEAU L., FOURNEL J., De MOL P., CAO M., ANGENOT L. and FREDERICH M., Screening of medicinal plants from Reunion island for antimalarial and cytotoxic activity, in Journal of Ethnopharmacology 120, 2008, 382-386.

PHILIPPE G., De MOL P., ANGENOT L., TITS M. and FREDERICH M., In vivo antimalarial activity of isosungucine, an indolomonoterpenic alkaloid from Strychnos icaja, in Planta Medica 73, 2007, 478-479.

FREDERICH M., TITS M., GOFFIN E., PHILIPPE G., GRELLIER P., De MOL P., HAYETTE M-P. and ANGENOT L., In vitro and In vivo antimalarial properties ofisostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, in Planta Medica 70, 2004, 520-525.

FREDERICH M., HAYETTE M-P., TITS M., De MOL P. and ANGENOT L., In vitro Activities of Strychnos Alkaloids and Extracts against Plasmodium falciparum, in Antimicrobial Agents and Chemotherapy 43,1999, 2328 – 2331.